What is the difference between PGD and PGS?

If you have a plan to do IVF, you can ask your doctor if you should be tested via PGS and PGD.To know the difference between PGD and PGS, first we should know what PGD or PGS is.As a short introduction, PGS testing is a genetic study of the embryos produced during your IVF cycle which has a goal of helping you have a successful pregnancy and a healthy baby.Stay tuned for more info!


What is PGD?

PGD is the abbreviation of Preimplantation genetic diagnosis. It’s a reproductive technology used along with an IVF cycle to increase the probability of a successful pregnancy and delivery.PGD is a genetic test on cells removed from embryos, to help select the best embryo(s) to achieve pregnancy or to avoid a genetic disease for which a couple is at risk.

PGD have different types that each one is used for a special disorder. Types such as PGT-A, PGT-M, PGT-SR.PGD may be considered in all IVF cycles; however, those who might benefit most from this test are couples at increased risk for chromosome abnormalities or specific genetic disorders.This includes women who have had several miscarriages, or who have had a prior pregnancy with a chromosome abnormality.


Women over 38 years and men with some forms of sperm abnormalities may produce embryos with higher rates of chromosome abnormalities.In addition, if a person carries a structural rearrangement of the chromosomes, PGD can identify which embryos have a normal amount of chromosomal material.

When there is a 25% or 50% chance to have a child affected with a specific genetic disease, PGD can be designed to identify which embryos are affected and which are unaffected. Then, only embryos without the disease are transferred to the uterus to attempt pregnancy.

Is PGD safe?

PGD is somehow embryo biopsy. It may raise concerns about the health of the embryo.The short answer to this question is Yes. Data from many years of PGD in animals and several hundred thousand live births in humans indicate that PGD does not lead to an increase in birth defects over that of the general population.

Research on the children born after PGD does not show any evidence for a detrimental effect of the process on growth or neurological development over the first several years of life.What’s more, in embryos where chromosomal PGD testing is done, fewer pregnancies ending in miscarriages can be expected due to chromosomal disorders.

 Simply because most abnormalities are identified prior to transfer of the embryos to the uterus. Removal of a few of the trophectoderm cells of the early embryo does not alter the ability of that embryo to develop into a complete, normal pregnancy.After this information about PGD, it’s PGS’s turn.

What is PGS?

PGS is a laboratory technique that allows for chromosomal analysis of the embryo before it is transferred to the womb to carry out the pregnancy.Chromosomes can be a good source to check the viability of the pregnancy. By undergoing a PGS before embryo implantation, it can be determined if there is a chromosomal abnormality and prevents consequences.

By PGS, you will be able to select the gender of your embryo and child so the embryologist may separate the selected gender for embryo transfer.


If an abnormality exists, embryo would not transfer and another fertility treatment course can begin immediately.If an abnormality leads to miscarriage, not only is it emotionally costly but also it’s a big step back for beginning a new fertility treatment process.

What is the difference between PGD and PGS?

Both PGD and PGS are embryo testing. PGD is a deeper analysis that goes beyond chromosomes to provide a genetic analysis before an embryo is transferred. PGD could checks recessive disorders like cystic fibrosis that might not manifest in the parents, but the embryos may carry the genes of the disease.

Also sex-related disorders about X or Y chromosome can be detected via PGD. In fact, PGD is a test for identifying embryos that are at high risk for inheriting a disorder.

PGS is not only to check the health and genetic conditions of the embryo. It can be a part of medical diagnosis to see what is the reason for infertility.If you’ve already suffered from multiple miscarriages, PGS may be able to shed light on the reasons why and helps to prevent it occurring again. PGS can address issues relating to infertility.

PGS could determine the gender of your embryos as well.

For providing genetic results of an embryo, a biopsy of a blastocyst embryo must be done by a professional embryologist.In general, PGD and PGS are similar in concept to a prenatal diagnosis. These tests can tell you many things about the embryos created via IVF prior to embryo transfer.

PGD and PGS have a significant effect on IVF success rate. After inventing these embryo tests, success rates have increased.Today this process became an inseparable part of IVF. What is the final goal of IVF? Isn’t it to get pregnant with a healthy embryo? These tests help reaching the goal without a risk, so why not?

After all, certainty is not a frequently-used-term in medical sciences. There can always be an unforeseen problem. The application of these tests is to prevent definite problems. Gathering enough facts and risk factors can give you the insight you desire regarding your baby.

While absolute certainty is hard to come by, still many different genetic conditions can be identified with PGS and PGD. You can also find out if the embryo being tested is viable for a successful pregnancy or not.

Although these tests recommend for all, you’re specially a good candidate If you already know that you or your partner have risk factors that may be passed onto your child.

Questions in this topic can be anxiety inducing. So don’t hesitate to ask any question of medical experts. If you have any questions about fertility services or testing, or you’re ready to get the process started, book an appointment online by TebMedTourism team to schedule a consultation today.

TebMedTourism team are always ready to answer you for free 24/7. Just contact us.

You may like to read : All about Surrogacy in Iran

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We start our professional activity in medical tourism industry regarding the profound capability of Iran in both healthcare & touristic fields.

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